Staphylococcus aureus bacteraemia is a common and very serious infection. S. aureus bacteraemia is associated with high rates of morbidity and mortality and its rapid and accurate diagnosis is vital. However the clinician must be able to distinguish between a bacteraemia caused by S.aureus, and bacteraemias caused by other Staphylococcus species (such as coagulase negative Staphylococci – CoNS) in order to choose the most appropriate therapy. In addition CoNS contaminants can also cause a ‘false positive’ diagnosis of S.aureus bacteraemia. As such accurate identification of Staphylococci to species level is extremely important.
Staphylococcus species look identical under the light microscope after gram staining, and further identification to species by culture methods can take 24-48 hours. As a precaution (in case the infection is due to S.aureus) Staphylococcal bacteraemias are frequently treated with vancomycin until a positive species ID becomes available. However as QuickFISH can distinguish between S.aureus and other Staphylococcus species in 20 minutes it can remove this requirement.
Staphylococcus QuickFISH provides a positive, unambiguous species ID in 20 minutes, and is based on the proven, patented PNA-FISH technology from AdvanDX.
Identification of CoNS in 20 minutes rather than 24-48 hours could deliver:
Identification of S.aureus in 20 minutes rather than 24-48 hours could deliver:
Staphylococcus QuickFISH allows clinicians to rapidly ensure early, appropriate therapy for patients with S.aureus bacteraemia, while minimising the unnecessary use of resources and broad spectrum antibiotics on those with CoNS.
Please see Instructions for Use (IFU) for complete performance data.
1. Forrest GN, Mehta S, Weekes E, Lincalis DP, Johnson JK, Venezia RA. Impact of rapid in situ hybridization testing on coagulase-negative staphylococci positive blood cultures. J Antimicrob Chemother. 2006 Jul;58(1):154-8
2. Ly T, Gulia J, Pyrgos V, Waga M, Shoham S. Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time. Ther Clin Risk Manag. 2008 Jun;4(3):637-40.